About Elastin

What is Elastin?

Elastin is a biopolymer that provides elastic recoil to connective tissues. It compliments the tensile strength of collagen and is found in the skin, blood vessels, heart, lungs, intestines, tendons, and ligaments.

A Basic Introduction
Wikipedia and the Elastagen website both offer a very basic introduction to elastin.  For a more detailed explanation, check out some of the reviews below.

  • Mithieux SM. Weiss AS. Elastin. Advances in Protein Chemistry. 70:437-61, 2005.
  • Kielty CM. Elastic fibres in health and disease. Expert Reviews in Molecular Medicine 8:1-23, 2006
  • Daamen WF. Veerkamp JH. van Hest JCM. van Kuppevelt TH. Elastin as a biomaterial for tissue engineering. Biomaterials 28:4378-98, 2007
  • Vrhovski B. Weiss AS. Biochemistry of tropoelastin. European Journal of Biochemistry. 258(1):1-18, 1998
  • Brooke BS. Bayes-Genis A. Li DY. New insights into elastin and vascular disease. Trends in Cardiovascular Medicine. 13(5):176-81, 2003
  • Debelle L. Tamburro AM. Elastin: molecular description and function. International Journal of Biochemistry & Cell Biology. 31(2):261-72, 1999
  • Kagan HM. Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. Journal of Cellular Biochemistry. 88(4):660-72, 2003
  • Keeley FW. Bellingham CM. Woodhouse KA. Elastin as a self-organizing biomaterial: use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self-assembly of elastin.Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences. 357(1418):185-9, 2002
  • Kielty CM. Sherratt MJ. Shuttleworth CA. Elastic fibres. Journal of Cell Science. 115(Pt 14):2817-28, 2002
  • Li B. Daggett V. Molecular basis for the extensibility of elastin. Journal of Muscle Research & Cell Motility. 23(5-6):561-73, 2002.
  • Urry DW. Parker TM. Mechanics of elastin: molecular mechanism of biological elasticity and its relationship to contraction. Journal of Muscle Research & Cell Motility. 23(5-6):543-59, 2002.
  • Urry DW. Hugel T. Seitz M. Gaub HE. Sheiba L. Dea J. Xu J. Parker T. Elastin: a representative ideal protein elastomer. Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences. 357(1418):169-84, 2002